Z2626
Zaragozic acid A trisodium salt
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
Sinonimo/i:
L-694,599, Squalestatin
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About This Item
Formula empirica (notazione di Hill):
C35H43O14Na3
Numero CAS:
Peso molecolare:
756.68
Numero MDL:
Codice UNSPSC:
12352106
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
Origine biologica
microbial
Livello qualitativo
Saggio
≥95% (HPLC)
Stato
lyophilized powder
Solubilità
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Applicazioni
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
Azioni biochim/fisiol
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
Note legali
Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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