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Merck
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Key Documents

SRP8017

Sigma-Aldrich

Progranulin rat

recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)

Sinonimo/i:

PEPI, Proepithelin

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About This Item

Numero CAS:
139316-59-9
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

rat

Ricombinante

expressed in HEK 293 cells

Tag

FLAG® tagged

Saggio

>95% (SDS-PAGE)

Forma fisica

lyophilized

PM

~65 kDa by SDS-PAGE

Confezionamento

pkg of 10 μg

Produttore/marchio commerciale

Sigma-Aldrich

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Impurezze

<0.1 EU/μg endotoxin, tested

Colore

white

N° accesso UniProt

P23785

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

rat ... Grn(29143)

Descrizione generale

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Stato fisico

Lyophilized from 0.2 μm-filtered solution in PBS.

Ricostituzione

Reconstitute with 100 μL deionized water.

Altre note

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.

Note legali

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury

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