SRP8010

GPX1 human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• Sinonimo/i: Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1
• Numero CAS: 1451392-36-1
• Codice UNSPSC: 12352200
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Ricombinante: expressed in E. coli
• Tag: His tagged
• Saggio: >90% (SDS-PAGE)
• Forma fisica: lyophilized
• PM: ~25 kDa by SDS-PAGE
• Confezionamento: pkg of 10 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• Impurezze: <1 EU/μg endotoxin, tested
• Colore: white
• N° accesso UniProt: P07203
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... GPX1(2876)

Descrizione

Descrizione generale

GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.

Azioni biochim/fisiol

GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.

Stato fisico

Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.

Ricostituzione

Reconstitute with 100 μL deionized water.

Altre note

Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable