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Key Documents

SRP6316

Sigma-Aldrich

Antithrombin III from human plasma

≥95% (SDS-PAGE)

Sinonimo/i:

SERPINC1

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized

PM

58 kDa

Confezionamento

pkg of 100 μg
pkg of 500 μg

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... SERPINC1(462)

Descrizione generale

SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors. The gene is mapped to human chromosome 1. SerpinC1 is a glycoprotein with three β-sheets and nine α-helices. The protein has an active site region and a heparin binding site.

Azioni biochim/fisiol

SerpinC1, also known as antithrombin III (AT III), has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. Antithrombin III synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus, it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. The inhibitory activity of AT III undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. Antithrombin III mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulation of many proinflammatory cytokines. It exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. The deficiency or functional abnormality of AT III may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that AT III can alter or influence inflammatory processes via inhibition of NF (nuclear factor)-κB activation or actin polymerization. It is found in normal serum at 15mg/100mL. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability. Reduction in the levels of antithrombin III enhances the severity of renal ischemia/reperfusion injury.

Stato fisico

Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl.

Ricostituzione

In water or aqueous buffer

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

nwg


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Plasma antithrombin III and thrombin generation time: correlation with hemoglobin A1 and fasting serum glucose in young diabetic women.
Sowers JR, et al.
Diabetes Care, 3, 655-658 (1980)
The anti-inflammatory properties of antithrombin III: new therapeutic implications.
Okajima K and Uchiba M
Seminars in Thrombosis and Hemostasis, 24, 27-32 (1998)
Antithrombin III supplementation in severe sepsis: beneficial effects on organ dysfunction.
Inthorn D, et al.
Shock, 8, 328-334 (1997)
Laboratory tests for antithrombin deficiency.
Khor B and Van Cott EM
American Journal of Hematology, 85, 947-950 (2010)
Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cells.
Oelschlager C, et al.
Blood, 99, 4015-4020 (2002)

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