SRP3076
IL-13 Variant human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinonimo/i:
interleukin 13
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥98% (HPLC)
≥98% (SDS-PAGE)
Forma fisica
lyophilized
PM
12.6 kDa
Confezionamento
pkg of 10 μg
tecniche
cell culture | mammalian: suitable
Impurezze
<0.1 EU/μg endotoxin, tested
Colore
white to off-white
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... IL13(3596)
Descrizione generale
IL13 (interleukin 13) is a classic cytokine produced by Th2 (T-helper) cells. This gene is localized to human chromosome 5q31, and is composed of four exons and three introns.
Recombinant human IL-13 is a 12.5 kDa protein consisting of 114 amino acid residues.
Recombinant human IL-13 is a 12.5 kDa protein consisting of 114 amino acid residues.
Applicazioni
IL-13 variant human has been used for the treatment of THP1 monocytes, along with with IL-4 and phorbol myristate acetate (PMA), to study the ability of SFN (sulforaphane) to induce THP1 differentiation into M2 macrophage cells.
Azioni biochim/fisiol
IL13 (interleukin 13) is up-regulated during parasitic infections, and participates in host′s protective immunity against Schistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes formation of liver granulomas in a CD4+ T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy. In adult subjects with ever-asthma, SNP (single nucleotide polymorphism) rs848 in this gene is linked with symptom severity.
Sequenza
MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
Stato fisico
Lyophilized from 10 mM Sodium Citrate, pH 4.0.
Ricostituzione
Centrifuge the vial prior to opening. Reconstitute in 20 mM Acetic Acid to a concentration of 0.1-0.5 mg/ml. Note: Allow the reconstituted vial to sit at 4°C for at >2 hours before use. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I clienti hanno visto anche
An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma.
Accordini S et al
PLoS ONE, 11(3), e0151292-e0151292 (2016)
Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes.
Pal S and Konkimalla VB
International Immunopharmacology, 35, 85-98 (2016)
IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD et al
Autophagy, 12(2), 397-409 (2016)
M Wills-Karp et al.
Science (New York, N.Y.), 282(5397), 2258-2261 (1998-12-18)
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4(+) T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a
Xin Long et al.
PloS one, 10(8), e0135360-e0135360 (2015-08-11)
The aim of this study was to determine whether two polymorphisms in the gene encoding IL13 previously associated with Schistosoma hematobium (S. hematobium) and S. mansoni infection are associated with S. japonicum infection. Single nucleotide polymorphisms (SNPs) rs1800925 (IL13/-1112C>T) and
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