SRP0120
Sirtuin 6 human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sinonimo/i:
NAD-dependent ADP-ribosyltransferase sirtuin-6, SIR2L6, SIRT6, sir2-like 6
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥70% (SDS-PAGE)
Stato
aqueous solution
PM
65 kDa
Confezionamento
pkg of 100 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
Concentrazione
>0.02 mg/mL
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... SIRT6(51548)
Descrizione generale
Sirtuin 6 (Sir6) is encoded by the gene mapped to human chromosome 19p13.3, a region linked with development of acute leukemia. Sir 6 is mainly expressed in bone cells and in the ovaries, but it is absent in the bone marrow. Sirt6 is a chromatin-associated protein localized specifically in nucleus.
Human Sirtuin 6, GenBank Accession No. NM_016539), full length with N-terminal ST tag, MW = 65kDa, expressed in Escherichia coli expression system.
Human Sirtuin 6, GenBank Accession No. NM_016539), full length with N-terminal ST tag, MW = 65kDa, expressed in Escherichia coli expression system.
Applicazioni
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Azioni biochim/fisiol
Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransferase, which catalyzes the transfer of ADP-ribose moiety from NAD to itself and histones. It has been implicated in the regulation of DNA repair, genomic stability and telomere integrity, gene expression, and metabolism. In addition, it also prevents age-related disorders and premature aging. Sir6 plays a vital role in the inhibition of nuclear factor-κB (NF-κB)–mediated inflammatory responses in rheumatoid joints. Hence, Sir6 is considered to be a potent target for treatment of rheumatoid arthritis (RA). Sir6 is also majorly implicated in the regulation of glucose and fat metabolism. Sir6 prevent cardiac hypertrophy in vitro via inhibiting NF-κB-dependent transcriptional activity and this effect is relied on its deacetylase activity.
Stato fisico
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.
Nota sulla preparazione
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
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Abhishek Bhardwaj et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(5), E538-E547 (2016-01-21)
SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis, and tumorigenesis. However, the role of SIRT6 deacetylase activity in its tumor-suppressor functions is not well understood. Here we report
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Schwer B
Proceedings of the National Academy of Sciences of the USA, 107(50), 21790-21794 (2010)
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
Mahlknecht U
International Journal of Oncology, 28(2), 447-456 (2006)
Minna Rahnasto-Rilla et al.
Chembiochem : a European journal of chemical biology, 17(1), 77-81 (2015-11-27)
Sirtuin 6 (SIRT6) is an NAD+-dependent histone deacetylase enzyme that is involved in multiple molecular pathways related to aging. Initially, it was reported that SIRT6 selectively deacetylated H3K9Ac and H3K56Ac; however, it has more recently been shown to preferentially hydrolyze long-chain
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.
Lee HS
Arthritis and Rheumatism, 65(7), 1776-1785 (2013)
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