SML2529

MDL-800

≥98% (HPLC)

• Sinonimo/i: Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate
• Formula empirica (notazione di Hill): C₂₁H₁₆BrCl₂FN₂O₆S₂
• Numero CAS: 2275619-53-7
• Peso molecolare: 626.30
• Numero MDL: MFCD31813709
• Codice UNSPSC: 41116158
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Fc1c(cc(c(c1)C)N[S](=O)(=O)c2c(cc(cc2)N[S](=O)(=O)c3cc(cc(c3)Cl)Cl)C(=O)OC)Br
• InChI: 1S/C21H16BrCl2FN2O6S2/c1-11-5-18(25)17(22)10-19(11)27-35(31,32)20-4-3-14(9-16(20)21(28)33-2)26-34(29,30)15-7-12(23)6-13(24)8-15/h3-10,26-27H,1-2H3; FKFQBYBODAKGOA-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

MDL-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family that is responsible for deacetylation of histones H3K9Ac and H3K56ac and has tumor suppressor activity. MDL-800 increased the deacetylase activity of SIRT6 by up to 22-fold resulting in a decrease in H3K9Ac and H3K56Ac in hepatocellular carcinoma (HCC) cells, causing cell cycle arrest and inhibiting their proliferation. It also suppressed the growth of xenografts of the hepatocellular carcinoma cell line BEL7405.

SIRT6 allosteric activator

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable