SML1795

Tenofovir

≥98% (HPLC)

• Sinonimo/i: (R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA
• Formula empirica (notazione di Hill): C₉H₁₄N₅O₄P
• Numero CAS: 147127-20-6
• Peso molecolare: 287.21
• Numero MDL: MFCD00943794
• Codice UNSPSC: 51111800
• ID PubChem: 329826070
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Attività ottica: [α]/D -20 to -26°, c = 0.5 in 1 M HCl
• Colore: white to beige
• Solubilità: H₂O: 2 mg/mL, clear (warmed)
• Temperatura di conservazione: −20°C
• Stringa SMILE: OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
• InChI: 1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1; SGOIRFVFHAKUTI-ZCFIWIBFSA-N

Descrizione

Azioni biochim/fisiol

Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus.

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription.

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable