SML1476

Thiocolchicoside

≥98% (HPLC)

• Sinonimo/i: (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• Formula empirica (notazione di Hill): C₂₇H₃₃NO₁₀S
• Numero CAS: 602-41-5
• Peso molecolare: 563.62
• Numero CE: 210-017-7
• Numero MDL: MFCD07995056
• Codice UNSPSC: 12352200
• ID PubChem: 329825907
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Attività ottica: [α]/D -510 to -610°, c = 0.5 in H₂O
• Colore: light yellow to dark yellow
• Solubilità: H₂O: 10 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1; LEQAKWQJCITZNK-AXHKHJLKSA-N

Descrizione

Azioni biochim/fisiol

Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H341,H361fd,H372
• Consigli di prudenza: P201 - P301 + P310 + P330
• Classi di pericolo: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Organi bersaglio: Gastro-intestinal system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable