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Merck
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Key Documents

SML1240

Sigma-Aldrich

Fondaparinux sodium

≥95% (HPLC)

Sinonimo/i:

Fondaparin sodium, Methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(14)-O-β-D-glucopyranuronosyl-(14)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(14)-O-2-O-sulfo-α-L-idopyranuronosyl-(14)-2-deoxy-2-(sulfoamino)-α-D-glucopyranoside 6-(hydrogen sulfate) sodium salt, SR-90107A

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About This Item

Formula empirica (notazione di Hill):
C31H43N3O49S8 · 10Na
Numero CAS:
114870-03-0
Peso molecolare:
1728.08
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥95% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: 20 mg/mL, clear

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

InChI

1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/q;10*+1/p-10/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1
XEKSTYNIJLDDAZ-JASSWCPGSA-D

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Applicazioni

Fondaparinux sodium has been used to test its neutralizing effect towards enterovirus D68-947 infection. It may be used in ultraviolet photodissociation (UVPD) measurements.

Azioni biochim/fisiol

Fondaparinux sodium is an antithrombotic anticoagulant, a Factor Xa inhibitor. Fondaparinux sodium is chemically related to low molecular weight heparins. Its pentasaccharide structure corresponds to the antithrombin III (ATIII) binding site of heparin. Fondaparinux sodium binding at this site potentiates the natural inhibitory effect of ATIII against factor Xa by a factor of approximately 300, which results in inhibition of thrombin generation.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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USP

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vibrant-m

D0070000

Dalteparin sodium

Hirudin recombinant, expressed in unspecified host, ≥7,000 ATU/mg protein (ATU = antithrombin units)

Sigma-Aldrich

H0393

Hirudin

vibrant-m

Y0001282

Heparin for physico-chemical analysis

USP

USP

1304118

Low Molecular Weight Heparin for Bioassays

Antithrombin III from human plasma lyophilized powder, ≥95% (SDS-PAGE)

Sigma-Aldrich

A2221

Antithrombin III from human plasma

Eparina Grade I-A, ≥180 USP units/mg

Sigma-Aldrich

H3393

Eparina

vibrant-m

H0200000

Heparin sodium

Penicillina-Streptomicina Solution stabilized, with 10,000 units penicillin and 10 mg streptomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture

Sigma-Aldrich

P4333

Penicillina-Streptomicina

Liam Doyle et al.
Nature chemical biology, 15(6), 632-640 (2019-05-01)
Several important Gram-negative bacterial pathogens possess surface capsular layers composed of hypervariable long-chain polysaccharides linked via a conserved 3-deoxy-β-D-manno-oct-2-ulosonic acid (β-Kdo) oligosaccharide to a phosphatidylglycerol residue. The pathway for synthesis of the terminal glycolipid was elucidated by determining the structures
Andrew B Dykstra et al.
Biomolecules, 3(4), 905-922 (2013-01-01)
Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma. To better characterize in vivo protein function, comprehensive knowledge of multimeric species, formed by
Xu Yang et al.
Journal of clinical pharmacology, 60(12), 1671-1678 (2020-07-09)
Hepatotoxicity with low-molecular-weight heparin (LMWH) or fondaparinux is a relatively common adverse reaction. This study assessed the effects of LMWH and fondaparinux on liver function in patients with pulmonary embolism based on a retrospective cohort. As a result, a total
David Ulbricht et al.
The Journal of biological chemistry, 292(3), 994-1004 (2016-12-13)
Many members of the serine protease inhibitor (serpin) family are activated by glycosaminoglycans (GAGs). Visceral adipose tissue-derived serpin (vaspin), serpin A12 of the serpin family, and its target protease kallikrein 7 (KLK7) are heparin-binding proteins, and inhibition of KLK7 by
Arun Kumar et al.
Journal of the American Heart Association, 8(10), e012184-e012184 (2019-05-10)
Background Fondaparinux sodium has been compared with low-molecular-weight heparins ( LMWH ) in randomized controlled trials for perioperative surgical thromboprophylaxis. However, the results from these studies are inconsistent in terms of efficacy and safety to reach a clinical decision. The
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