SML1132

Pep2-8 trifluoroacetate salt

≥95% (HPLC), contains 58μL of solution at 10mM in DMSO

• Sinonimo/i: Ac-TVFTSWEEYLDWV-NH₂ trifluoroacetate salt, Ac-TVFTSWEEYLDWV-amide trifluoroacetate salt, Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt
• Formula empirica (notazione di Hill): C₈₃H₁₁₀N₁₆O₂₄ · xC₂HF₃O₂
• Peso molecolare: 1715.85 (free base basis)
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥95% (HPLC)
• Forma fisica: solution
• Colore: colorless to pale yellow
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C

Descrizione

Amino Acid Sequence

Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt

Azioni biochim/fisiol

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells.

Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A), serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding. It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable