SML1053

LMK235

≥98% (HPLC)

• Sinonimo/i: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide
• Formula empirica (notazione di Hill): C₁₅H₂₂N₂O₄
• Numero CAS: 1418033-25-6
• Peso molecolare: 294.35
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 20 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: N(OCCCCCC(=O)NO)C(=O)c1cc(cc(c1)C)C
• InChI: 1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19); VRYZCEONIWEUAV-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

LMK-235 induces the differentiation of odontoblasts in dental pulp cells. It plays an important role in the regeneration of dental tissue.

LMK235 is a histone deacetylase (HDAC) inhibitor with greater potency against HDAC4 and HDAC5 (IC₅₀ = 11.9 and 4.2 nM, respectively) than other HDAC family members (IC₅₀ values = HDAC1 320 nM, HDAC2 881 nM, HDAC6 55.7 nM, and HDAC8 1278 nM). LMK235 potentiates the cytotoxic effects of cisplatin, and sensitizes platinum-drug resistant tumor cell lines to cisplatin toxicity.

LMK235 is a histone deacetylase (HDAC) inhibitor; HDAC4- and HDAC5-preferring.

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable