SML0668
Calhex 231 hydrochloride
≥98% (HPLC)
Sinonimo/i:
4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
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About This Item
Formula empirica (notazione di Hill):
C25H27ClN2O · HCl
Numero CAS:
Peso molecolare:
443.41
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
![Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) ≥95% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/235/466/8e0939d2-d5f9-46ee-ad12-f28fe40c308a/640/8e0939d2-d5f9-46ee-ad12-f28fe40c308a.png)
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Condizioni di stoccaggio
desiccated
Colore
white to beige
Solubilità
DMSO: 15 mg/mL, clear
Temperatura di conservazione
−20°C
Applicazioni
Calhex 231 hydrochloride has been used:
- as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
- to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
- to test its effect on acoustic response bias in zebrafish
- in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )
Azioni biochim/fisiol
Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR.
Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC50 of 0.36 μM.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Toshiya Minakata et al.
Frontiers in molecular neuroscience, 12, 175-175 (2019-08-06)
Maintaining Ca2+ homeostasis in lymphatic fluids is necessary for proper hearing. Despite its significance, the mechanisms that maintain the cochlear lymphatic Ca2+ concentrations within a certain range are not fully clarified. We investigated the functional expression of calcium-sensing receptor (CaSR)
Roshan A Jain et al.
Current biology : CB, 28(9), 1357-1369 (2018-04-24)
Animals continuously integrate sensory information and select contextually appropriate responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli from a pre-existing choice repertoire in a context-dependent manner. We demonstrate that this sensorimotor choice is modulated
Pamela Mattar et al.
International journal of molecular sciences, 21(20) (2020-10-21)
Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines through autophagy in preadipocytes. Our aim is to understand the role of CaSR on autophagy in AT
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