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SML0069

Sigma-Aldrich

NSC 33994

≥98% (HPLC)

Sinonimo/i:

(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6

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About This Item

Formula empirica (notazione di Hill):
C28H42N2O2
Numero CAS:
82058-16-0
Peso molecolare:
438.65
Numero MDL:
MFCD20488055
Codice UNSPSC:
12352200
ID PubChem:
329825133
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to tan

Solubilità

DMSO: ≥25 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2

InChI

1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+
QFNJFVBKASKGEU-OCEACIFDSA-N

Applicazioni

NSC 33994 may be used in Jak2-mediated cell signaling studies.

Azioni biochim/fisiol

NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
061M4619V

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Guido Di Dalmazi et al.
BMJ open diabetes research & care, 8(2) (2020-10-30)
The COVID-19 pandemic forced the Italian government to issue extremely restrictive measures on daily activities since 11 March 2020 ('lockdown'), which may have influenced the metabolic control of type 1 diabetes mellitus (T1D). The aims of the study were to
Juliet Chepngeno et al.
Veterinary research, 50(1), 84-84 (2019-10-24)
Rotavirus C (RVC) has been detected increasingly in humans and swine in different countries, including the US. It is associated with significant economic losses due to diarrheal disease in nursing piglets. In this study we aimed: (1) to determine the
Elena Eremeeva et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(40), 9560-9576 (2017-05-18)
The ability of various nucleoside triphosphate analogues of deoxyguanosine and deoxycytidine with 7-deazadeoxyadenosine (A
Tetsushi Yoshikawa et al.
Journal of medical virology, 91(6), 1008-1013 (2019-01-29)
The main aims of the present study were to elucidate the systemic group A rotavirus (RVA) infection and to clarify the genetic changes of persistent virus in the X-linked severe combined immunodeficiency (SCID) patient. RotaTeq vaccine (RV5) genotype-specific real-time reverse
Yuehui Wang et al.
Methods (San Diego, Calif.), 173, 32-43 (2019-06-22)
Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification
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