SMB00378

Diallyl disulfide

≥98% (HPLC)

• Sinonimo/i: Allyl disulfide, Diallyl disulfide
• Formula condensata: CH₂=CHCH₂SSCH₂CH=CH₂
• Numero CAS: 2179-57-9
• Peso molecolare: 146.27
• Beilstein: 1699241
• Numero CE: 218-548-6
• Numero MDL: MFCD00008656
• Codice UNSPSC: 12352200
• ID PubChem: 329824979
• NACRES: NA.25

Proprietà

• Origine biologica: Allium sativum L.
• Livello qualitativo: 200
• Densità del vapore: >5 (vs air)
• Tensione di vapore: 1 mmHg ( 20 °C)
• Saggio: ≥98% (HPLC)
• Stato: oil
• Colore: colorless to yellow
• Indice di rifrazione: n20/D 1.541 (lit.)
• P. ebollizione: 180-195 °C (lit.)
• Densità: 1.008 g/mL at 25 °C (lit.)
• applicazioni: metabolomics; vitamins, nutraceuticals, and natural products
• Temperatura di conservazione: −20°C
• Stringa SMILE: C=CCSSCC=C
• InChI: 1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2; PFRGXCVKLLPLIP-UHFFFAOYSA-N

Descrizione

Descrizione generale

Diallyl disulfide (DADS) is an oil-soluble volatile organosulfur compound that can be naturally found in Allium sativum (garlic). It has a simple chemical structure with two sulfur atoms attached with two allyl groups. This constitute of garlic contributes to its pungent aroma.

Applicazioni

Diallyl disulfide has been used:

• to study its effects in apoptosis induction and cell viability on different glioma cell lines
• as a treatment and positive control to assess the anti-inflammatory regulation of nuclear factor erythroid-2 related factor-2 (Nrf2) in breast cancer cells
• as a potential substrate compound to detect hydrogen sulfide (H₂S) production via lead acetate/lead sulfide method

Azioni biochim/fisiol

Diallyl disulfide is a potent anticancer agent. It can reduce carcinogen-induced cancers and shows anti-proliferative effects in both in vivo and in vitro models. DADS enhances the anti-obesity and anti-inflammatory effects of green tea in high-fat/high-sucrose (HF/HS) diet-fed mice. It also displays antioxidant, anti-microbial, cardiovascular protective, and neuroprotective activities. DADS elicits anti-mitotic and anti-neoplastic effects and arrests mitosis in colon neoplastic lesions in vivo and colon tumor cell growth in vitro experiments.

Organosulfur compound that is naturally found in garlic. Contributes to the pungent odor of crushed garlic. Anticancer agent and may provide protection against cardiovascular disease.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H315,H319,H335
• Consigli di prudenza: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 143.6 °F - closed cup
• Punto d’infiammabilità (°C): 62 °C - closed cup