SAB5700534

Anti-Phospho-PLN-S16 antibody produced in rabbit

• Sinonimo/i: CMD1P, CMH18, PLB, PLN
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: 6
• Reattività contro le specie: rat, mouse, human
• Concentrazione: 0.65 mg/ml
• tecniche: western blot: 1:500-1:2000
• N° accesso UniProt: P26678
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pSer16)
• Informazioni sul gene: human ... PLN(5350)

Descrizione

Descrizione generale

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Immunogeno

A phospho specific peptide corresponding to residues surrounding S16 of human PLN

Stato fisico

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stoccaggio e stabilità

Store at -20℃. Avoid freeze / thaw cycles.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable