SAB5500188

Anti-URI antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP215, affinity isolated antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41
• Coniugato: unconjugated
• application: FACS; IHC
• Clone: SP215, monoclonal
• Reattività contro le specie: human (tested)
• tecniche: flow cytometry: 1:100; immunohistochemistry: 1:100

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Ricombinante: expressed in proprietary host
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: SP215, monoclonal
• Reattività contro le specie: human (tested)
• Reattività contro le specie (prevista in base all’omologia): bovine, mouse
• tecniche: flow cytometry: 1:100; immunohistochemistry: 1:100
• Isotipo: IgG
• N° accesso UniProt: O94763
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... URI1(8725)

Descrizione

Descrizione generale

Unconventional prefoldin RPB5 interactor (URI) is an oncogene required for the survival of some human carcinomas and is often amplified and over-expressed in subsets of carcinomas from ovary, breast, stomach, and lung. Activation of URI contributes an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition. URI can negatively modulate RNA polymerase II subunit 5 (RPB5) and mediates resistance of cells to cisplatin.

Immunogeno

Synthetic peptide derived from the C-terminus of the human URI protein.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable