SAB5500103

Anti-F4/80 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP115, affinity isolated antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Ricombinante: expressed in proprietary host
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: SP115, monoclonal
• Reattività contro le specie: mouse (tested)
• Reattività contro le specie (prevista in base all’omologia): rat
• tecniche: immunohistochemistry: 1:100
• Isotipo: IgG
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ADGRE1(2015)

Descrizione

Descrizione generale

EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) is a human homolog of F4/80, an eosinophil-specific receptor. It is abundantly expressed on leukocytes. F4/80 is a member of the GPCR superfamily. It has N-terminal EGF (epidermal growth factor)-like domains bound to a seven-span transmembrane (7TM) moiety through a mucin-like spacer domain. This gene is located on human chromosome 19p13.

Mouse EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1) or cell surface glycoprotein F4/80 is a cell surface glycoprotein and a member of the EGF TM7 family of proteins. It shares 68% overall amino acid identity with human EGF-module-containing-mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.

Immunogeno

Synthetic peptide derived from N-terminus of mouse F4/80 protein.

Applicazioni

Anti-F4/80 antibody has been used in immunohistochemistry.

Azioni biochim/fisiol

In liquid bone marrow cultures, F4/80/EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) acts as a maturation marker for mononuclear phagocytes. EMR1 can be used as a target molecule in the treatment of individuals suffering from squamous cell carcinoma and eosinophilic disorders.

Caratteristiche e vantaggi

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Stato fisico

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable