SAB5200055

Monoclonal Anti-KCNB1 antibody produced in mouse

clone S4-11, 1 mg/mL, purified immunoglobulin

• Sinonimo/i: Anti-DRK1PC, Anti-Kcnb1, Anti-Kcr1-1, Anti-Kv2.1, Anti-Kv2.1, S4-11, Anti-Shab
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: S4-11, monoclonal
• Forma fisica: buffered aqueous glycerol solution
• PM: antigen predicted mol wt 105-125 kDa
• Reattività contro le specie: human, mouse, rat, monkey
• Concentrazione: 1 mg/mL
• tecniche: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotipo: IgG1
• N° accesso NCBI: NP_037318
• N° accesso UniProt: Q14721
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: rat ... Kcnb1(25736)

Descrizione

Descrizione generale

The potassium voltage-gated channel subfamily B member 1 (KCNB1) gene is mapped to human chromosome 20q13.13. This gene codes for a α subunit of voltage-gated potassium Kv2.1 channel. The encoded protein contains 858 amino acids and six transmembrane segments (S1–S6). KCNB1 is mainly expressed in the central nervous system, but at high level in somatodendritic compartment of neocortical and pyramidal neurons.

Specificità

Detects ~105-125 kDa. Recognizes the Shab related α-subunit Kv2.1.

Immunogeno

Bacterially expressed GST Bacterially expressed GSTfusion protein corresponding toamino acids 509-853 of rat KV2.1, Accession Number NM_004975.

Azioni biochim/fisiol

Potassium voltage-gated channel subfamily B member 1 (KCNB1) plays a vital role in hippocampal neuron excitation homeostasis. The encoded protein is mainly implicated in the generation of the major delayed rectifier potassium current in pyramidal neurons. Mutation in the gene is associated with the development of left ventricular (LV) hypertrophy and early-onset infantile epilepsy in humans.

Caratteristiche e vantaggi

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Stato fisico

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable