SAB4700031

Monoclonal Anti-CD1A-PE antibody produced in mouse

clone HI149, purified immunoglobulin, buffered aqueous solution

• Codice UNSPSC: 12352203
• NACRES: NA.44

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: phycoerythrin (R-PE) conjugate
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: HI149, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable
• Isotipo: IgG1
• N° accesso NCBI: NM_001763.2
• N° accesso UniProt: P06126
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CD1A(909)

Descrizione

Descrizione generale

CD1a molecule is a lipid-presenting protein, which is highly expressed on Langerhans cells. It belongs to the CD1 protein family and is encoded by the gene mapped to human chromosome 1.

The antibody HI149 reacts with CD1a (T6), a 49 KDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.

Immunogeno

Human thymocytes

Applicazioni

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Azioni biochim/fisiol

CD1a acts as a potential target for treatment against inflammatory skin diseases. The encoded protein functions as a phenotypic marker of human epidermal Langerhans cells (LC). CD1a mediates the presentation of lipids to induce T cell activation resulting in the production of interleukin-22 (IL-22), IL-13 and interferon (IFN)γ.

Caratteristiche e vantaggi

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Stato fisico

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable