SAB4504268

Anti-phospho-TAK1 (pThr¹⁸⁴) antibody produced in rabbit

affinity isolated antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 67 kDa
• Reattività contro le specie: human, rat, mouse
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:1000; western blot: 1:500-1:1000
• N° accesso NCBI: O43318
• N° accesso UniProt: O43318
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pThr184)
• Informazioni sul gene: human ... MAP3K7(6885)

Descrizione

Descrizione generale

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is encoded by MAP3K7. TAK1 is a 606-residue protein, that contains a serine-threonine/tyrosine-protein kinase catalytic domain and a C-terminal coiled-coil domain. It is a member of the mitogen-activated protein kinase kinase kinase family (MAP3K). This gene is mapped to human chromosome 6q15.

Immunogeno

The antiserum was produced against synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184.

Immunogen Range: 161-210

Azioni biochim/fisiol

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) participates in the mitogen-activated protein kinase (MAPK)-p38 signaling pathway. This gene also participates in the autophagy process in retinal pigment epithelial cells. Mutations in MAP3K7 result in cardiospondylocarpofacial syndrome.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable