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Key Documents

SAB4503479

Sigma-Aldrich

Anti-FGF18 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

FGF-18, Fibroblast growth factor 18, Zfgf5

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 23 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

N° accesso NCBI

O76093

N° accesso UniProt

O76093

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... FGF18(8817)

Descrizione generale

Anti-FGF18 Antibody detects endogenous levels of total FGF18 protein.
FGF18 (fibroblast growth factor 18) is a member of the paracrine-acting FGF8 subfamily. It is expressed in the perichondrium and joints of developing long bones. FGF18 is a 21.2 kDa glycosylated secretory protein, that is structurally similar to FGF8 and FGF17. It is mapped to human chromosome 5q35.1. Anti-FGF18 Antibody detects endogenous levels of total FGF18 protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human FGF18.

Immunogen Range: 151-200

Azioni biochim/fisiol

FGF18 (fibroblast growth factor 18) plays an important role in the skeletal development of the embryonic and adult organism. It is associated with colorectal and ovarian cancer. FGF18 participates in cell proliferation and differentiation during osteogenesis and chondrogenesis. It is essential for the growth of bone, cartilage, hair, cardiovasculature and alveolus.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.
Ohbayashi N, et al.
Genes & Development, 16(7), 870-879 (2002)
The crystal structure of fibroblast growth factor 18 (FGF18).
Alan B, et al.
Protein & cell, 5(5), 343?347-343?347 (2014)
Wei Wei et al.
The Journal of clinical investigation, 123(10), 4435-4448 (2013-09-11)
High-throughput genomic technologies have identified biomarkers and potential therapeutic targets for ovarian cancer. Comprehensive functional validation studies of the biological and clinical implications of these biomarkers are needed to advance them toward clinical use. Amplification of chromosomal region 5q31-5q35.3 has
Nobuyuki Itoh et al.
Trends in genetics : TIG, 20(11), 563-569 (2004-10-12)
Fibroblast growth factors (Fgfs) and Fgf receptors (Fgfrs) comprise a signaling system that is conserved throughout metazoan evolution. Twenty-two Fgfs and four Fgfrs have been identified in humans and mice. During evolution, the Fgf family appears to have expanded in

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