Passa al contenuto
Merck
Tutte le immagini(2)

Key Documents

SAB4502244

Sigma-Aldrich

Anti-CYTL1 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

C4orf4, Cytokine-like protein 1, Protein C17

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 15 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CYTL1(54360)

Descrizione generale

Anti-CYTL1 antibody detects endogenous levels of total CYTL1 protein.
The CYTL1 (cytokine like 1) gene is mapped to human chromosome 4p16.2. The gene was first discovered in CD34(+) cells of the bone marrow and cord blood. The encoded protein is predominantly expressed in chondrocytes.

Immunogeno

The antiserum was produced against synthesized peptide derived from human CYTL1.

Immunogen Range: 61-110

Azioni biochim/fisiol

In vitro studies reveal that Cytl1 (cytokine like 1) acts as an autocrine or paracrine regulatory factor in the process of cartilage formation. CYTL1, being homologous with IL-2 (interleukin-2), is considered as a potential cytokine that is involved in regulating immune responses. CYTL1 is known to be associated with the pathogenesis of rheumatoid arthritis and osteoarthritis.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Tanja Vukićević et al.
Journal of the American Society of Nephrology : JASN, 30(5), 795-810 (2019-04-17)
Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. This pathway fine-tunes renal water reabsorption and urinary concentration, and its perturbation
Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model.
Tomczak A
Proteins: Structure, Function, and Genetics, 79(4), 1277-1292 (2011)
Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Wang X
Journal of Immunology, 196(10), 4090-4099 (2016)
Yue Tan et al.
Frontiers in immunology, 8, 478-478 (2017-05-10)
The initial infection and transmission of HIV-1 requires C-C chemokine receptor type 5 (CCR5). Here, we report that the membrane-proximal region (MPR, aa 22-38) of CCR5 participates in the infection of HIV-1. First, MPR-specific antibodies elicited in mice dose-dependently inhibited
Xiaolin Wang et al.
Oncoimmunology, 8(5), e1577126-e1577126 (2019-05-10)
CYTL1 is a novel cytokine that was first identified in CD34+ hematopoietic cells. We previously prepared recombinant CYTL1 and verified that it chemoattracted human monocytes via the CCR2/ERK pathway. It has been reported that CYTL1 plays contradictory roles in neuroblastoma

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.