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Key Documents

SAB4502167

Sigma-Aldrich

Anti-PECAM-1 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

CD31, CD31 antigen, EndoCAM, PEC1, PECA1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 82 kDa

Reattività contro le specie

mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... PECAM1(5175)

Categorie correlate

Descrizione generale

Anti-PECAM-1 Antibody detects endogenous levels of total PECAM-1 protein.
The platelet and endothelial cell adhesion molecule 1 (PECAM1) gene, spanning 75-kb, is mapped on the long arm of human chromosome 17. This gene codes for 130-kD protein, which belongs to the immunoglobulin (Ig) superfamily. It is a vital component of the endothelial cell intercellular junction. PECAM1 is expressed on the surface of circulating platelets, monocytes, neutrophils and selected T-cell subsets.

Immunogeno

The antiserum was produced against synthesized peptide derived from human PECAM-1.

Immunogen Range: 686-735

Applicazioni

Anti-PECAM-1, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Azioni biochim/fisiol

Platelet and endothelial cell adhesion molecule 1 (PECAM1) also called as cluster of differentiation 31 (CD31), plays a crucial role in the adhesion cascade leading to leukocyte extravasation during the inflammatory process. PECAM1 is essential for leukocyte transmigration via intercellular junctions of vascular endothelial cells. Genetic polymorphism of PECAM1 is associated with atherosclerotic events. PECAM1, is a membrane glycoprotein that facilitates both homophilic and heterophilic adhesion. PECAM1 is also implicated in angiogenesis.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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