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Documenti fondamentali

SAB4501719

Sigma-Aldrich

Anti-LAMA4 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

LAMA4, Laminin subunit α-4

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 202 kDa

Reattività contro le specie

mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... LAMA4(3910)

Descrizione generale

Anti-LAMA4 Antibody detects endogenous levels of total LAMA4 protein.
Laminin-A4 (LAMA4) is a protein that is expressed at high levels in vivo in clusters of hypertrophic chondrocytes. It is located on human chromosome 6q21.

Immunogeno

The antiserum was produced against synthesized peptide derived from human LAMA4.

Immunogen Range: 481-530

Applicazioni

Anti-LAMA4 antibody has been used in western blotting, immunohistochemistry and immunocytochemistry.

Azioni biochim/fisiol

Laminin-A4 (LAMA4) decreases the amount of cellular protrusions in cultured human chondrocytes. It participates in migration, proliferation and survival of several cells. LAMA4 induces invasion, migration and angiogenesis of trophoblast cell.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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The laminin family.
Aumailley M.
Cell adhesion & migration, 7(1), 48-55 (2013)
N Shan et al.
Placenta, 36(8), 809-820 (2015-06-11)
The laminin α4 subunit (LAMA4) has been shown to promote migration, proliferation, and survival of various cell types. This study investigated LAMA4's role in trophoblast cells during placental development. LAMA4 expression was immunohistochemically assessed in the first trimester and term
Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas.
Shan N, et al,
Placenta, 36(8), 809?820-809?820 (2015)
Effect of Laminin?A4 inhibition on cluster formation of human osteoarthritic chondrocytes.
Moazedi?Fuerst FC, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(3), 419-426 (2016)
Jyoti Gautam et al.
Scientific reports, 6, 36450-36450 (2016-11-04)
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been

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