SAB4500599
Anti-CDCA2 antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
FLJ25804, MGC129906, MGC129907, cell division cycle associated 2
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Clone:
polyclonal
application:
ELISA
WB
WB
Reattività contro le specie:
human
tecniche:
ELISA: 1:1000
western blot: 1:500-1:1000
western blot: 1:500-1:1000
citations:
4
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen 112 kDa
Reattività contro le specie
human
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:1000
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CDCA2(157313)
Descrizione generale
Cell division cycle associated 2 (CDCA2) is expressed in the nucleus. The gene encoding it is localized on human chromosome 8p21.2. Anti-CDCA2 Antibody detects endogenous levels of total CDCA2 protein.
Immunogeno
The antiserum was produced against synthesized peptide derived from human CDCA2.
Immunogen Range: 511-560
Immunogen Range: 511-560
Azioni biochim/fisiol
Cell division cycle associated 2 (CDCA2) dephosphorylates histone H3 and modulates DNA damage responses. It has roles in nuclear envelope reformation and chromatin reorganization. The protein has been shown to be upregulated in neuroblastoma tumors and melanoma cell lines.
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Pauline Lagarde et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(5), 608-615 (2013-01-16)
Synovial sarcoma (SS) occurs in both children and adults, although metastatic events are much more common in adults. Whereas the importance of the t(X;18) translocation in SS oncogenesis is well established, the genetic basis of SS metastasis is still poorly
Paola Vagnarelli et al.
Nucleus (Austin, Tex.), 3(2), 138-142 (2012-05-05)
Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner:
Paola Vagnarelli
Advances in experimental medicine and biology, 773, 401-414 (2014-02-25)
Nuclear structure and chromatin changes are very useful biomarkers in cancer diagnosis. Despite this, their biological significance and relevance to cancer progression are still not well understood. The identification of new proteins that link the nuclear envelope to chromatin organization
Fumihiko Uchida et al.
PloS one, 8(2), e56381-e56381 (2013-02-19)
Cell division cycle associated 2 (CDCA2) recruits protein phosphatase 1 to chromatin to antagonize activation of ataxia telangiectasia mutated (ATM)-dependent signal transduction. ATM kinase plays a critical role in the DNA damage response and its phosphorylation cascade to inhibit the
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