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Merck
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Documenti fondamentali

SAB4300507

Sigma-Aldrich

Anti-GRIA1 (Ab-849) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-GLUH1 antibody produced in rabbit, Anti-GLUR1 antibody produced in rabbit, Anti-GLURA antibody produced in rabbit, Anti-HBGR1 antibody produced in rabbit, Anti-glutamate receptor, ionotropic, AMPA 1 antibody produced in rabbit

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About This Item

Numero MDL:
MFCD01323382
Codice UNSPSC:
12352203
NACRES:
NA.41
Coniugato:
unconjugated
application:
WB
Clone:
polyclonal
Reattività contro le specie:
human, rat, mouse
citations:
6
tecniche:
western blot: 1:500-1:1000

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

~110 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

1 mg/mL

tecniche

western blot: 1:500-1:1000

Isotipo

IgG

Sequenza immunogenica

( Q-Q-S-I-N)

N° accesso NCBI

NP_000818.2

N° accesso UniProt

P42261

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GRIA1(2890)

Immunogeno

Peptide sequence around aa. 847-851 ( Q-Q-S-I-N ), according to the protein GRIA1.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Raccomandato

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
951421253

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Jian Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 14919-14933 (2014-11-08)
Abnormal accumulation of β-amyloid (Aβ) is the major neuropathological hallmark of Alzheimer's disease (AD). However, the mechanisms underlying aberrant Aβ formation in AD remain unclear. We showed previously that inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that metabolizes the
Shun Hamada et al.
The European journal of neuroscience, 40(8), 3136-3146 (2014-08-19)
The N-methyl-D-aspartate receptor (NMDAR) plays various physiological and pathological roles in neural development, synaptic plasticity and neuronal cell death. It is composed of two GluN1 and two GluN2 subunits and, in the neonatal hippocampus, most synaptic NMDARs are GluN2B-containing receptors
Shuang Qiu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(40), 13505-13515 (2014-10-03)
Long-term potentiation of glutamatergic transmission has been observed after physiological learning or pathological injuries in different brain regions, including the spinal cord, hippocampus, amygdala, and cortices. The insular cortex is a key cortical region that plays important roles in aversive
Sarah L Ferri et al.
Hormones and behavior, 66(2), 409-420 (2014-07-06)
Ovarian hormones act in multiple brain regions to modulate specific behaviors and emotional states. For example, ovarian hormones promote female sexual receptivity in the hypothalamic ventromedial nucleus (VMH) and modulate anxiety in the amygdala. Hormone-induced changes within the VMH include
Y N Liu et al.
European journal of pain (London, England), 18(8), 1120-1128 (2014-01-21)
Inhibition of Src-family protein tyrosine kinases (SFKs) in spinal dorsal horn has been established as an effective strategy for the alleviation of chronic pathological pain. As one of the important SFKs members, Fyn kinase is critical for synaptic plasticity and
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