SAB4200769
Anti-Human IgG3-Peroxidase antibody, Mouse monoclonal
clone HP-6050, purified from hybridoma cell culture
Sinonimo/i:
Anti-Human immunoglobulin G3
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.46
Coniugato:
peroxidase conjugate
application:
ELISA (d)
Clone:
HP-6050, monoclonal
Reattività contro le specie:
human
citations:
1
tecniche:
direct ELISA: 1:80,000-1:160,000 using 2 μg/mL human IgG3 for coating.
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
peroxidase conjugate
Forma dell’anticorpo
purified from hybridoma cell culture
Tipo di anticorpo
primary antibodies
Clone
HP-6050, monoclonal
Stato
lyophilized powder
Reattività contro le specie
human
Concentrazione
~2 mg/mL
tecniche
direct ELISA: 1:80,000-1:160,000 using 2 μg/mL human IgG3 for coating.
Isotipo
IgG1
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Descrizione generale
Human IgG consist of four subclasses (1-4) that can be recognized by the antigenic difference in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. Each subclass has different biological and physiochemical properties. The IgG subclass may be preferentially produced in response to different antigens and pathological conditions. For instance, anti-polysaccharide responses are mainly of the IgG2 subclass while protein antigens responses give rise to IgG1 and IgG3 antibodies. IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial cells, while IgG2 and IgG4 are far less efficient. The abundance of the different IgG subclasses in the bloodstream varies with age, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels rise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. IgG3 deficiency has been associated with a patient′s history of recurrent infectious that may lead to chronic lung disease. Decreased IgG3 levels are frequently associated with IgG1 deficiency. Examination of the distribution pattern of IgG subclasses in different types of diseases may provide insight into the related immunological processes and may assist in the diagnosis of various disorders.
Immunogeno
Human IgG3 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads
Applicazioni
Direct ELISA: a working dilution of 1:80,000-1:160,000 is recommended using 2 μg/mL human IgG3 for coating.
Stato fisico
Supplied as a lyophilized powder.
Altre note
In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.
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Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Sens. 1
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Management of the patient with IgG subclass deficiency and/or selective antibody deficiency.
H G Herrod
Annals of allergy, 70(1), 3-8 (1993-01-01)
V A Oxelius
The American journal of medicine, 76(3A), 7-18 (1984-03-30)
The isotypes of IgG, IgG1, IgG2, IgG3, and IgG4 were determined in immunoglobulin preparations and the effect on serum levels of treated patients. Serum IgG subclass deficiencies were recorded in different patient groups: (1) IgG2-IgG4 deficiency was associated with IgA
J C Lima-Junior et al.
Vaccine, 29(9), 1801-1811 (2011-01-11)
The Plasmodium vivax Merozoite Surface Protein-3α (PvMSP-3α) is considered as a potential vaccine candidate. However, the detailed investigations of the type of immune responses induced in naturally exposed populations are necessary. Therefore, we aim to characterize the naturally induced antibody
R Stevens et al.
Journal of clinical immunology, 3(1), 65-69 (1983-01-01)
Peripheral blood leukocytes from individuals immunized with tetanus toxoid can be stimulated by pokeweed mitogen to produce IgG anti-tetanus toxoid antibody (IgG-Tet) in vitro. Previous studies have shown that treatment of these cells with tetanus toxoid or anti-human IgG reagents
F W van der Meulen et al.
British journal of haematology, 46(1), 47-56 (1980-09-01)
The purpose of this study was to determine whether quantitative or qualitative factors are of major importance in the destruction of red cells sensitized with incomplete warm autoantibodies of subclass IgG1. To that end, the relative amount of igG1 antibody
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