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Key Documents

SAB4200593

Sigma-Aldrich

Anti-Occludin antibody from rabbit

affinity isolated antibody

Sinonimo/i:

BLCPMG, OCLN, PPP1R115

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Reattività contro le specie

human

tecniche

immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

N° accesso UniProt

Q16625

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... OCLN(100506658)

Descrizione generale

Occludin (OCLN) is an integral membrane protein, encoded by the gene mapped to human chromosome 5q13.2. OCLN is a ~65 kDa protein with four transmembrane domains including, a long COOH-terminal cytoplasmic domain, a short NH2-terminal cytoplasmic domain, two extracellular loops, and one intracellular turn. It is specifically localized at tight junctions (TJ).

Applicazioni

Anti-Occludin antibody from rabbit has been used in immunocytochemistry and western blotting.

Azioni biochim/fisiol

Occludin (OCLN), along with tight junction (TJ)-associated peripheral membrane proteins, plays a vital role in formation and regulation of TJ. The encoded protein facilitates the translocation of p85a to TJs to regulate actin organization after oxidative stress. OCLN is also implicated in cell migration. Mutation in the gene leads to the development of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG).

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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The tight junction protein, occludin, regulates the directional migration of epithelial cells.
Du D, et al.
Developmental Cell, 18(1), 52-63 (2010)
Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin.
Mikio F, et al.
The Journal of Cell Biology, 141(7), 1539?1550-1539?1550 (1998)
Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry.
Kohaar I, et al.
Journal of Virology, 84(14), 6987-6994 (2010)
Complex phenotype of mice lacking occludin, a component of tight junction strands.
Saitou M, et al.
Molecular Biology of the Cell, 11(12), 4131-4142 (2000)
Recessive Mutations in the Gene Encoding the Tight Junction Protein Occludin Cause Band-like Calcification with Simplified Gyration and Polymicrogyria.
Mary C O, et al.
American Journal of Human Genetics, 87(3), 354?364-354?364 (2010)
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