SAB4200102

Anti-AS160 (C-terminal) antibody produced in rabbit

~1.5 mg/mL

• Sinonimo/i: Anti-Akt substrate of 160 kDa, Anti-TBC1D4 (TBC1 domain family, member 4)
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• PM: antigen ~160 kDa
• Reattività contro le specie: human
• Confezionamento: antibody small pack of 25 μL
• Convalida avanzata: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentrazione: ~1.5 mg/mL
• tecniche: western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells overexpressing human AS160
• N° accesso UniProt: O60343
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TBC1D4(9882)

Descrizione

Descrizione generale

AS160 is a protein kinase B (Akt) substrate of 160 kDa, also known as TBC1D4. This gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating protein (RabGAP). It has a number of insulin-regulatable protein kinase B (AKT) phosphomotifs. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.

Applicazioni

Anti-AS160 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Azioni biochim/fisiol

AS160 (protein kinase B (Akt) substrate) is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. AS160 is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.

Stato fisico

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable