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Key Documents

SAB3500306

Sigma-Aldrich

Anti-Slc22A17 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-BOCT, Anti-BOIT, Anti-Brain-type organic cation transporter, Anti-Solute carrier family 22 member 17

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

predicted mol wt 59 kDa

Reattività contro le specie

rat, human, mouse

tecniche

immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable

N° accesso NCBI

Q8WUG5

N° accesso UniProt

Q8WUG5

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SLC22A17(51310)

Descrizione generale

Slc22A17 gene is also referred to as brain organic cation transporter (BOCT) and is mapped to human chromosome 14q11.2. The encoded protein is predominantly localized to kidney and liver. The Slc22 proteins consists of 12 transmembrane (TM) α-helices with an extended loop (extracellular) between the first and the second transmembrane regions, and a loop (intracellular) between the sixth and the seventh transmembrane regions.

Immunogeno

Slc22A17 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human Slc22A17.

Azioni biochim/fisiol

Slc22A17 expression is associated with important biological processes such as cell differentiation, apoptosis and inflammation. Slc22A17 mediates endocytosis of neutrophil gelatinase-associated lipocalin, a mammalian protein that can bind to bacterial siderophore enterobactin with high affinity.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500306.

Stato fisico

Supplied in PBS with 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Biochemical and structural characterization of the interaction between the Siderocalin NGAL/LCN2 and the N-terminal domain of its endocytic receptor SLC22A17.
Martinez A I C, et al.
The Journal of Biological Chemistry (2015)
Josefin A Jacobsson et al.
Genomics, 90(5), 595-609 (2007-08-24)
The solute carrier family 22 (SLC22) is a large family of organic cation and anion transporters. These are transmembrane proteins expressed predominantly in kidneys and liver and mediate the uptake and excretion of environmental toxins, endogenous substances, and drugs from
Yudan Chi et al.
Science (New York, N.Y.), 369(6501), 276-282 (2020-07-18)
The tumor microenvironment plays a critical regulatory role in cancer progression, especially in central nervous system metastases. Cancer cells within the cerebrospinal fluid (CSF)-filled leptomeninges face substantial microenvironmental challenges, including inflammation and sparse micronutrients. To investigate the mechanism by which

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