SAB2702176

Monoclonal Anti-TERF1 antibody produced in mouse

• Sinonimo/i: TRF, TRF1, hTRF1-AS, t-TRF1
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 4E4; monoclonal
• Forma fisica: liquid
• PM: 70 kDa
• Reattività contro le specie: human
• Concentrazione: 1 mg/mL
• tecniche: immunocytochemistry: suitable; immunofluorescence: suitable
• Isotipo: IgG1
• N° accesso UniProt: P54274
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TERF1(7013)

Descrizione

Immunogeno

Human TRF1

Applicazioni

For ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher.

Azioni biochim/fisiol

TRF1 binds the double-stranded telomeric repeat sequence, TTAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.

Caratteristiche e vantaggi

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Stato fisico

Phosphate-buffered saline, no preservative added.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable