SAB2500431
Anti-FTL antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-Ferritin L subunit, Anti-L apoferritin, Anti-MGC71996
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
goat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
Reattività contro le specie
rat, mouse, human
tecniche
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... FTL(2512)
Categorie correlate
Descrizione generale
Ferritin light (FTL) subunit along with ferritin heavy (FTH) subunit are members of the ferritin complex. FTL gene is mapped on the human chromosome at 19q13.33.
Immunogeno
Peptide with sequence C-GEYLFERLTLKHD from the C Terminus of the protein sequence according to NP_000137.2.
Applicazioni
Anti-FTL antibody produced in goat has been used in western blotting (1:500).
Azioni biochim/fisiol
Ferritin light (FTL) subunit is an important protein in iron metabolism but lacks catalytic activity. This protein participates in the nucleation and mineralization of the iron center. FTL acts as a biomarker to differentiate between malignant and benign tumors. Overexpression of the FTL gene is observed in several malignant tumors and plays an important role in mediating the malignancy of cancers. FTL gene plays a role in the pathogenesis of glioblastoma. Mutation or deletion of the FTL gene is associated with neuroferritinopathy.
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Sara Zumerle et al.
Blood, 123(23), 3646-3650 (2014-03-22)
Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder.
Lorena Fernandes Arruda et al.
PloS one, 8(4), e61058-e61058 (2013-04-18)
Iron is an essential element. However, in its free form, iron participates in redox-reactions, leading to the production of free radicals that increase oxidative stress and the risk of damaging processes. Living organisms have an efficient mechanism that regulates iron
Jean-Christophe Deschemin et al.
Frontiers in physiology, 8, 804-804 (2017-11-02)
Pulmonary iron excess is deleterious and contributes to a range of chronic and acute inflammatory diseases. Optimal lung iron concentration is maintained through dynamic regulation of iron transport and storage proteins. The iron-regulatory hormone hepcidin is also expressed in the
Jean-Christophe Deschemin et al.
PloS one, 10(12), e0145685-e0145685 (2015-12-29)
Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Patients with CF suffer from chronic infections and severe inflammation, which lead to progressive pulmonary
Tingfeng Wu et al.
PloS one, 11(2), e0149361-e0149361 (2016-02-13)
Accumulating evidence suggests that iron-associated proteins contribute to tumor initiation and development. Ferritin light chain (FTL), a key protein in iron metabolism, is associated with the survival of glioblastoma multiforme (GBM) patients; however, the molecular mechanisms underlying this association remain
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