SAB1300669

Anti-SULT2B1a/b (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinonimo/i: Anti-Alcohol sulfotransferase, Anti-HSST2, Anti-Hydroxysteroid sulfotransferase SULT2B1b, Anti-Sulfotransferase family, cytosolic, 2B, member 1, isoform b
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: IgG fraction of antiserum
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: indirect ELISA: 1:1000; western blot: 1:100-1:500
• N° accesso NCBI: NP_004596
• N° accesso UniProt: O00204
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SULT2B1(6820)

Descrizione

Descrizione generale

Cytosolic sulfotransferases (STs or SULTs) encodes hydroxysteroid sulfotransferase (SULT2B1), the isoforms of which are SULT2B1a and SULT2B1b. By PCR with human placental and prostate cDNA as template, they isolated 2 alternatively spliced cDNAs, identical throughout most of their sequences, but having different 5-prime ends. The shorter cDNA, SULT2B1a, encodes a protein of 350 amino acids; the longer cDNA, SULT2B1b, encodes a 365-amino acid protein. Genomic PCR analysis revealed that the gene encoding both cDNAs, SULT2B1, contains 7 exons, with 2 alternative first exons being used to generate SULT2B1a and SULT2B1b. Northern blot analysis revealed that the SULT2B1 gene is expressed as a 1.4-kb transcript predominantly in prostate, placenta, and trachea. In human chromosome, the gene SULT2B1a/b is localized on 19q13.3.

Immunogeno

SULT2B1A/B (NP_004596, 1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SULT2B1a/b.

Azioni biochim/fisiol

Cytosolic sulfotransferases (STs or SULTs) catalyse the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. SULT2B1 is involved in the synthesis and metabolism of steroids, which is essential for skin development and skin barrier function. Mutations in SULT2b1a/b gene leads to increased keratinocyte proliferation and altered cholesterol metabolism, resulting in autosomal-recessive congenital ichthyosis (ARCI). SULT2B1 catalyses the sulfation of an androgen precursor, dehydroepiandrosterone (DHEA) and hence polymorphism within this gene may lead to prostate tumor.

Stato fisico

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable