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S8251

Sigma-Aldrich

Succinylcholine chloride dihydrate

98.0-102.0%, solid

Sinonimo/i:

Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride

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About This Item

Formula condensata:
[(CH3)3NCH2CH2OCOCH2]2Cl2 · 2H2O
Numero CAS:
6101-15-1
Peso molecolare:
397.34
Beilstein:
3922827
Numero CE:
200-747-4
Numero MDL:
MFCD00150564
Codice UNSPSC:
41116107
ID PubChem:
24277873
NACRES:
NA.77

Saggio

98.0-102.0%

Forma fisica

solid

Colore

white

Solubilità

H2O: complete 100 mg/ml, clear to slightly hazy, colorless
H2O: soluble (unstable at pH > 9.)

Ideatore

Novartis

Stringa SMILE

O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

InChI

1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2
FFSBEIRFVXGRPR-UHFFFAOYSA-L

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Applicazioni

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.4,5

Azioni biochim/fisiol

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.
Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.3

Caratteristiche e vantaggi

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Ricostituzione

Solutions may be stored for several days at 4 °C.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Consigli di prudenza

P301 + P310

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area. In certain
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