S5951

SW02

• Sinonimo/i: 4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester
• Formula empirica (notazione di Hill): C₁₉H₂₃BrN₂O₅
• Numero CAS: 1010820-68-4
• Peso molecolare: 439.30
• Numero MDL: MFCD17215960
• Codice UNSPSC: 12352200
• ID PubChem: 329824558
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: powder
• Colore: white to off-white
• Solubilità: DMSO: ≥20 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCOC(=O)C1=C(C)N(CCCC(=O)OC)C(=O)NC1c2ccc(Br)cc2
• InChI: 1S/C19H23BrN2O5/c1-4-27-18(24)16-12(2)22(11-5-6-15(23)26-3)19(25)21-17(16)13-7-9-14(20)10-8-13/h7-10,17H,4-6,11H2,1-3H3,(H,21,25); YFZRMRYVWWUQME-UHFFFAOYSA-N

Descrizione

Applicazioni

SW02 may be used in Hsp70-mediated cell signaling studies.

Azioni biochim/fisiol

SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfolding, such as tau and Aβ in Alzheimer′s. SW02 increases Hsp70 ATPase activity, resulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptide, as shown by treatment with SW02.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable