S5576
SKA-31
≥98% (HPLC)
Sinonimo/i:
Naphtho[1,2-d]thiazol-2-ylamine
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About This Item
Formula empirica (notazione di Hill):
C11H8N2S
Numero CAS:
Peso molecolare:
200.26
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
NACRES:
NA.25
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Solubilità
DMSO: ≥30 mg/mL
Temperatura di conservazione
−20°C
Stringa SMILE
Nc1nc2c(ccc3ccccc23)s1
InChI
1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
FECQXVPRUCCUIL-UHFFFAOYSA-N
Azioni biochim/fisiol
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Eye Irrit. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance calcium-activated potassium channels, and to evaluate its influence on endothelium-derived hyperpolarization (EDH)-KCa2.3/KCa3.1 type relaxation in isolated endothelium-intact
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