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Key Documents

Altri documenti

S0758

Sigma-Aldrich

Sulfaphenazole

≥98%

Sinonimo/i:

4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide

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About This Item

Formula empirica (notazione di Hill):
C15H14N4O2S
Numero CAS:
526-08-9
Peso molecolare:
314.36
Numero CE:
208-384-3
Numero MDL:
MFCD00057226
Codice UNSPSC:
12352204
ID PubChem:
24278198
NACRES:
NA.77

Saggio

≥98%

Forma fisica

powder

Solubilità

ethanol: 25 mg/mL, clear, colorless to yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3

InChI

1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
QWCJHSGMANYXCW-UHFFFAOYSA-N

Informazioni sul gene

human ... CYP2C18(1562) , CYP2C19(1557) , CYP2C9(1559)

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Applicazioni

Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations.

Azioni biochim/fisiol

Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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4-Hydroxymephenytoin

Sigma-Aldrich

UC126

4-Hydroxymephenytoin

USP

USP

1446859

Montelukast sodium

Tienilic Acid ≥98% (HPLC)

Sigma-Aldrich

SML0505

Tienilic Acid

Sulfamonomethoxine

Sigma-Aldrich

S0508

Sulfamonomethoxine

Quinidine crystallized, ≥98.0% (dried material, NT)

Sigma-Aldrich

22600

Quinidine

BRAND® microplate BRANDplates®, pureGrade size 384 wells, size 120 μL, flat bottom, black, with transparent bottom

BR781627

BRAND® microplate BRANDplates®, pureGrade

Noncompetitive inhibition of human CYP 2C9 in vitro by a commercial Rhodiola rosea product
Thu OKF, et al.
Pharmacology Research & Perspectives, 5(4), e00324-e00324 (2017)
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Moraes CB, et al.
SLAS discovery, 24(3), 346-361 (2019)
Simon Lucas et al.
Journal of medicinal chemistry, 51(24), 8077-8087 (2008-12-04)
Pyridine substituted naphthalenes (e.g., I-III) constitute a class of potent inhibitors of aldosterone synthase (CYP11B2). To overcome the unwanted inhibition of the hepatic enzyme CYP1A2, we aimed at reducing the number of aromatic carbons of these molecules because aromaticity has
Simon Lucas et al.
Journal of medicinal chemistry, 51(19), 6138-6149 (2008-09-04)
Pharmacophore modeling of a series of aldosterone synthase (CYP11B2) inhibitors triggered the design of compounds 11 and 12 by extending a previously established naphthalene molecular scaffold (e.g., present in molecules 1 and 2) via introduction of a phenyl or benzyl
Chengqun Huang et al.
American journal of physiology. Heart and circulatory physiology, 298(2), H570-H579 (2009-12-17)
Previously, we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia-reperfusion (I/R) injury (Ref. 15). The mechanism, however, underlying this cardioprotection, is largely unknown. With evidence that activation of autophagy
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