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Merck
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Key Documents

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S0193

Sigma-Aldrich

SKF-86002

≥98% (HPLC), solid

Sinonimo/i:

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

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About This Item

Formula empirica (notazione di Hill):
C16H12N3FS
Numero CAS:
72873-74-6
Peso molecolare:
297.35
Numero MDL:
MFCD00869367
Codice UNSPSC:
12352200
ID PubChem:
24724598
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

protect from light

Colore

off-white

Punto di fusione

189-190 °C (lit.)

Solubilità

DMSO: soluble >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
YOELZIQOLWZLQC-UHFFFAOYSA-N

Informazioni sul gene

human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)

Azioni biochim/fisiol

p38 MAP kinase inhibitor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Donna E Muscarella et al.
Toxicological sciences : an official journal of the Society of Toxicology, 68(1), 82-92 (2002-06-21)
Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the
Ganesan Ramesh et al.
American journal of physiology. Renal physiology, 289(1), F166-F174 (2005-02-11)
Cisplatin is an important chemotherapeutic agent but can cause acute renal injury. Part of this acute renal injury is mediated through tumor necrosis factor-alpha (TNF-alpha). The pathway through which cisplatin mediates the production of TNF-alpha and injury is not known.
M Kusuhara et al.
Circulation research, 83(8), 824-831 (1998-10-20)
Activation of the Na+/H+ exchanger isoform-1 (NHE-1) by angiotensin II is an early signal transduction event that may regulate vascular smooth muscle cell (VSMC) growth and migration. Many signal transduction events stimulated by angiotensin II are mediated by the mitogen-activated
Javier Hernández Losa et al.
Oncogene, 22(26), 3998-4006 (2003-06-25)
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as
David J Diller et al.
Current topics in medicinal chemistry, 5(10), 953-965 (2005-09-24)
In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors long before the identity of the p38 kinase was known. During
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