RAB0695
Human IL21 / Interleukin-21 ELISA Kit
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About This Item
Codice UNSPSC:
41116158
NACRES:
NA.32
Prodotti consigliati
Reattività contro le specie
human
Confezionamento
kit of 96 wells (12 strips x 8 wells)
tecniche
ELISA: suitable
input
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 110 pg/mL
standard curve range: 125-8000 pg/mL
Metodo di rivelazione
colorimetric
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... IL21(59067)
Descrizione generale
Interleukin-21 (IL-21) is a pleiotropic cytokine. It belongs to the common γ-chain cytokines with broad pleiotropic actions. This gene is located on human chromosome 4q27.
Applicazioni
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Azioni biochim/fisiol
Interleukin-21 (IL-21) regulates chronic viral infection, thereby plays a major role for immune responses in a mouse model of HBV (hepatitis B virus) infection. This gene is linked to celiac disease, rheumatoid arthritis (RA), type 1 diabetes mellitus (type 1 DM) and psoriatic arthritis. IL-21 has the ability to promote maturation and increase the cytotoxicity of CD8+ T cells and natural killer (NK) cells.
The antibody pair provided in this kit recognizes Human Interleukin-21.
Altre note
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Met. Corr. 1
Codice della classe di stoccaggio
8A - Combustible corrosive hazardous materials
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Yong Liu et al.
International immunopharmacology, 22(1), 98-106 (2014-07-01)
The frequency of different subsets of CD4(+)CXCR5(+) TFH cells and serum cytokine levels were analyzed in a total of 14 patients with newly diagnosed hepatitis B virus-associated membranous nephropathy (HBV-MN), 12 individuals with immune-tolerant HBV infection (HBV-IT) and 12 healthy
Yolanda P Alemán-García et al.
Journal of immunology research, 2021, 6630715-6630715 (2021-03-26)
Systemic lupus erythematosus is characterized by high levels of IgG class autoantibodies that contribute to the pathophysiology of the disease. The formation of these autoantibodies occurs in the germinal centers, where there is cooperation between follicular T helper cells (TFH)
Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis
Albers HM, et al.
Arthritis and Rheumatism, 60(3), 60(3)-60(3) (2009)
Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort
de Armas LR, et al.
Journal of Immunology (2017)
Sheng Cheng et al.
International journal of clinical and experimental medicine, 7(10), 3202-3208 (2014-11-25)
Asthma is characterized by airway inflammation, mucus overproduction, and airway hyperreactivity. Cytokines, especially T helper 2-derived cytokines interleukin (IL)-4, IL-5, and IL-13, are involved in the pathogenesis of asthma. IL-21 has a variety of effects on the immune system. However
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