R1402

Raloxifene hydrochloride

solid

• Sinonimo/i: Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
• Formula empirica (notazione di Hill): C₂₈H₂₇NO₄S · HCl
• Numero CAS: 82640-04-8
• Peso molecolare: 510.04
• Numero MDL: MFCD01938233
• Codice UNSPSC: 51111800
• ID PubChem: 24278673
• NACRES: NA.77

Proprietà

• Stato: solid
• Livello qualitativo: 100
• Colore: light yellow
• Solubilità: DMSO: soluble 28 mg/mL; H₂O: insoluble
• Ideatore: Eli Lilly
• Stringa SMILE: Cl[H].Oc1ccc(cc1)-c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4
• InChI: 1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H; BKXVVCILCIUCLG-UHFFFAOYSA-N
• Informazioni sul gene: human ... ESR2(2100)

Descrizione

Applicazioni

Raloxifene hydrochloride has been used:

• as a competitive inhibitors for estrogen receptor α in breast cancer cells
• as an anti-resorptive agents to test its effect on improving bone mineral density (BMD) in six-month-old female ovariectomized rats
• to test effect on viability of esophageal adenocarcinoma cells

Azioni biochim/fisiol

Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.

Raloxifene is benzothiophene compound and is used in treating postmenopausal osteoporosis It comparatively induces lesser risk in developing thromboembolic events and cataracts compared to tamoxifen. Raloxifene also interacts with estrogen receptors and plasma proteins.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H351,H361d
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Carc. 2 - Repr. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)