PZ0007

Azithromycin dihydrate

≥98% (HPLC), powder, 50S ribosomal subunit formation and elongation inhibitor

• Sinonimo/i: 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10- trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylohexopyranosyl]oxy]-, [2R-(2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)]- dihydrate, N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A, CP-62993
• Formula empirica (notazione di Hill): C₃₈H₇₂N₂O₁₂ · 2H₂O
• Numero CAS: 117772-70-0
• Peso molecolare: 785.02
• Numero MDL: MFCD01862248
• Codice UNSPSC: 12352200
• ID PubChem: 329823676
• NACRES: NA.77

Proprietà

• Nome del prodotto: Azithromycin dihydrate, ≥98% (HPLC)
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: protect from light
• Colore: off-white
• Solubilità: DMSO: >20 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: O.O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1; SRMPHJKQVUDLQE-KUJJYQHYSA-N

Descrizione

Applicazioni

Azithromycin dihydrate has been used:

• in blocking buffer (5% bovine serum albumin) for indirect immunofluorescence
• in treating the U87 cells for cell-viability assay and flow cytometry analysis to study the Zika virus infection in glial cells
• in antibiotic co-treatment experiments, to compare its antibacterial activity with PYRRO-C3D against Streptococcus pneumoniae biofilms

Azioni biochim/fisiol

Azithromycin dihydrate is a macrolide antibiotic with anti-immunomodulatory/anti-inflammatory properties.

Azithromycin dihydrate is a macrolide antibiotic, azalide subclass. It binds to the 50S subunit of the 70S bacterial ribosomes and inhibits RNA-dependent protein synthesis in bacterial cells. Azithromycin also has anti-immunomodulatory/anti-inflammatory properties, which make it useful in treating cystic fibrosis.

Azithromycin is a non-β-lactam antibody, effective against infections associated with respiratory tract, skin, tissues and genital chlamydia. It also acts against Plasmodium falciparum and P. vivax, which are multidrug resistance species that transmit malaria. Azithromycin targets the ribosome and prevents protein synthesis. It is soluble in lipids and metabolizes in liver by undergoing demethylation.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable