P9703

Pimaricin

from Streptomyces chattanoogensis, ≥95% (HPLC)

• Sinonimo/i: Natamycin
• Formula empirica (notazione di Hill): C₃₃H₄₇NO₁₃
• Numero CAS: 7681-93-8
• Peso molecolare: 665.73
• Numero CE: 231-683-5
• Numero MDL: MFCD00135085
• Codice UNSPSC: 51102829
• ID PubChem: 24899055
• NACRES: NA.85

Proprietà

• Origine biologica: Streptomyces chattanoogensis
• Livello qualitativo: 300
• Saggio: ≥95% (HPLC)
• Stato: lyophilized powder; powder
• Solubilità: 0.1% formic acid in methanol: soluble 1 mg/mL
• Spettro attività antibiotica: fungi
• applicazioni: agriculture; environmental
• Modalità d’azione: cell membrane | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C[C@@H]1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@](O)(C[C@@H](O)C[C@H]3O[C@@H]3\C=C\C(=O)O1)C[C@H](O)[C@H]2C(O)=O)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O
• InChI: 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1; NCXMLFZGDNKEPB-FFPOYIOWSA-N

Descrizione

Descrizione generale

Chemical structure: macrolide

Applicazioni

Pimaricin is an amphoteric antibiotic from Streptomyces chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. Pimaricin is used as a fungicide in agar media. It is used to study the pleitropic regulator AdpAch and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis.

Azioni biochim/fisiol

An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane

Altre note

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C. Light sensitive.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)