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Documenti fondamentali

P9607

Sigma-Aldrich

Anti-Potassium Channel Kv2.1 (DRK1) antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

Reattività contro le specie

rat

tecniche

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:250-1:500

N° accesso UniProt

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KCNB1(3745)
mouse ... Kcnb1(16500)
rat ... Kcnb1(25736)

Immunogeno

synthetic peptide corresponding to amino acids 837-853 of rat potassium channel Kv2.1 (with an additional N-terminal cysteine and tyrosine).The epitope is identical in mouse and rat and highly homologous in human and pig.

Stato fisico

Lyophilized at ∼1 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.05% sodium azide.

Nota sulla preparazione

Protein A purified.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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J S Trimmer
Proceedings of the National Academy of Sciences of the United States of America, 88(23), 10764-10768 (1991-12-01)
Antibodies specific for the drk1 polypeptide were used to characterize the corresponding protein in rat brain. Recombinant and synthetic immunogens containing fragments of the drk1 polypeptide were produced. Antibodies raised to these immunogens display monospecific reactions with the same 130-kDa
G Shi et al.
The Journal of biological chemistry, 269(37), 23204-23211 (1994-09-16)
We have transiently expressed the rat Kv2.1 K+ channel polypeptide (pKv2.1) at high levels by transfection of mammalian COS-1 cells. Kv2.1-transfected cells express a molecular mass of 108 kDa pKv2.1, larger than the size of the core polypeptide (95 kDa)
G C Frech et al.
Nature, 340(6235), 642-645 (1989-08-24)
Voltage-activated potassium channels play an important part in the control of excitability in nerve and muscle. Different K+ channels are involved in establishing the resting potential, determining the duration of action potentials, modulation of transmitter release, and in rhythmic firing
P M Hwang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(4), 1569-1576 (1993-04-01)
We have localized CDRK and DRK1, two novel K+ channels of the Shab subfamily by immunohistochemistry. The two channels are closely related in structure with about 90% amino acid identity in the N-terminal and middle portions and 60% identity in
Marjaana A Peltola et al.
EMBO reports, 12(12), 1293-1299 (2011-11-08)
Kv2.1 is a potassium channel α-subunit abundantly expressed throughout the brain. It is a main component of delayed rectifier current (I(K)) in several neuronal types and a regulator of excitability during high-frequency firing. Here we identify AMIGO (amphoterin-induced gene and

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