P6126

(R)-(−)-fenilefrina

≥99% (titration), powder, α₁-adrenoceptor agonist

• Sinonimo/i: (R)-(−)-1-(3-idrossifenil)-2-metilamminoetanolo, Alcol (R)-(−)-3-idrossi-α-(metilamminometil)benzilico
• Formula condensata: HOC₆H₄CH(CH₂NHCH₃)OH·HCl
• Numero CAS: 61-76-7
• Peso molecolare: 203.67
• Beilstein: 4158948
• Numero CE: 200-517-3
• Numero MDL: MFCD00012605
• Codice UNSPSC: 12352200
• ID PubChem: 57654535
• NACRES: NA.77

Proprietà

• product name: (R)-(−)-fenilefrina, powder
• Forma fisica: powder
• Punto di fusione: 143-145 °C (lit.)
• Ideatore: Johnson & Johnson
• Stringa SMILE: OC1=CC([C@H](CNC)O)=CC=C1.Cl
• InChI: 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1; OCYSGIYOVXAGKQ-FVGYRXGTSA-N
• Informazioni sul gene: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descrizione

Descrizione generale

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.

Applicazioni

(R)-(-)-Phenylephrine hydrochloride has been used:

• in the preparation and culturing of cardiocytes and fibroblasts
• to stimulate myocardial strips to measure slice contraction
• in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
• to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
• to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality

Azioni biochim/fisiol

α₁-adrenoceptor agonist.

Caratteristiche e vantaggi

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H317
• Consigli di prudenza: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classi di pericolo: Acute Tox. 4 Oral - Skin Sens. 1B
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves