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P3029

Phencyclidine hydrochloride

Name: Phencyclidine hydrochloride
Brand: SIGMA

Sinonimo/i:

1-(1-Phenylcyclohexyl)piperidine hydrochloride, PCP hydrochloride

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About This Item

Formula empirica (notazione di Hill):

C₁₇H₂₅N · HCl

Numero CAS:

956-90-1

Peso molecolare:

279.85

Numero MDL:

MFCD00058208

Codice UNSPSC:

12352200

ID PubChem:

329820160

NACRES:

NA.77

Prodotti consigliati

Slide 1 of 1

1 of 1

Supelco

P-003

PCP-D₅(Phencyclidine-D₅) solution

Forma fisica

powder

Livello qualitativo

300

Controllo stupefacenti

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

Solubilità

H₂O: 11.2 mg/mL
0.1 M HCl: 18.4 mg/mL
methanol: 30 mg/mL

Stringa SMILE

Cl.C1CCN(CC1)C2(CCCCC2)c3ccccc3

InChI

1S/C17H25N.ClH/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18;/h1,4-5,10-11H,2-3,6-9,12-15H2;1H
BUAJNGPDPGKBGV-UHFFFAOYSA-N

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Azioni biochim/fisiol

σ opioid receptor agonist and psychostimulant; inhibits NMDA glutamate receptor activation by binding to an allosteric site within the ion channel.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Glutamate Receptors (Ion Channel Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H336

Consigli di prudenza

P301 + P310 + P330

Classi di pericolo

Acute Tox. 3 Oral - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential.

R H Porter et al.

Journal of neurochemistry, 64(2), 614-623 (1995-02-01)

Quantitative receptor autoradiography was used to examine the regional binding characteristics of a diverse group of N-methyl-D-aspartate (NMDA)-receptor channel blockers that varied in potency 10(5)-fold. Full competition curves were generated in each of six brain regions for 11 different compounds.

Deep posteromedial cortical rhythm in dissociation.

Sam Vesuna et al.

Nature, 586(7827), 87-94 (2020-09-18)

Advanced imaging methods now allow cell-type-specific recording of neural activity across the mammalian brain, potentially enabling the exploration of how brain-wide dynamical patterns give rise to complex behavioural states1-12. Dissociation is an altered behavioural state in which the integrity of

Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.

Xin Chen et al.

Journal of medicinal chemistry, 55(16), 7141-7153 (2012-08-01)

Functionally selective G protein-coupled receptor (GPCR) ligands, which differentially modulate canonical and noncanonical signaling, are extremely useful for elucidating key signal transduction pathways essential for both the therapeutic actions and side effects of drugs. However, few such ligands have been

Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans.

Bita Moghaddam et al.

Schizophrenia bulletin, 38(5), 942-949 (2012-08-18)

Here, we describe our collaborative efforts to use N-methyl-d-aspartate (NMDA) receptor antagonists as a translational tool to advance our understanding of the pathophysiology of schizophrenia and identify potential new targets for treatment of schizophrenia. We began these efforts in the

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.

M Ingallinesi et al.

Molecular psychiatry, 20(8), 951-958 (2014-08-27)

Gpr88, an orphan G-protein-coupled receptor, is highly and almost exclusively expressed in the medium spiny projection neurons of the striatum, and may thus participate in the control of motor functions and cognitive processing that are impaired in neuropsychiatric disorders such

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