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P2795

Sigma-Aldrich

Phytosphingosine hydrochloride

greener alternative

Sinonimo/i:

4-Hydroxysphinganine, PHS

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About This Item

Formula empirica (notazione di Hill):
C18H39NO3 · HCl
Numero CAS:
554-62-1
Peso molecolare:
353.97
Numero MDL:
MFCD06804643
Codice UNSPSC:
12352211
ID PubChem:
24898363
NACRES:
NA.25

Forma fisica

powder

Livello qualitativo

200

Punteggio alternativa più verde

old score: 19
new score: 9
Find out more about DOZN™ Scoring

Caratteristiche più verdi

Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Categoria alternativa più verde

, Re-engineered

Tipo di lipide

sphingolipids

Temperatura di conservazione

−20°C

Stringa SMILE

Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO

InChI

1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
GDKAAHDFPOWGQE-RXQQAGQTSA-N

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Azioni biochim/fisiol

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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