O4636

Oxytetracycline dihydrate

Assay (anhydrous basis) 95.0%-102.0%

• Sinonimo/i: 5-Hydroxytetracycline dihydrate, Oxytetracycline, Oxytetracycline Anhydrous
• Formula empirica (notazione di Hill): C₂₂H₂₄N₂O₉ · 2H₂O
• Numero CAS: 6153-64-6
• Peso molecolare: 496.46
• Numero CE: 201-212-8
• Numero MDL: MFCD00151234
• Codice UNSPSC: 51284038
• ID PubChem: 24898000
• NACRES: NA.85

Proprietà

• Livello qualitativo: 200
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: protein synthesis | interferes
• Stringa SMILE: O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• InChI: 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1; IBZHEBHGZFICKS-IFLJXUKPSA-N

Descrizione

Descrizione generale

Chemical structure: tetracycline

Applicazioni

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.

Azioni biochim/fisiol

Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Risultati analitici

solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions

Altre note

10g,50g

Keep container tightly closed in a dry and well-ventilated place.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H361d,H411
• Consigli di prudenza: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classi di pericolo: Aquatic Chronic 2 - Repr. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)