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M1508

Sigma-Aldrich

4-Methylumbelliferone sodium salt

fluorogenic, ≥98% (HPLC), crystalline

Sinonimo/i:

β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin

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About This Item

Formula condensata:
C10H7O3Na
Numero CAS:
5980-33-6
Peso molecolare:
198.15
Numero CE:
227-790-1
Numero MDL:
MFCD00069856
Codice UNSPSC:
12352204
ID PubChem:
24896658
NACRES:
NA.32

product name

4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline

Livello qualitativo

200

Saggio

≥98% (HPLC)

Forma fisica

crystalline

Colore

yellow

Solubilità

water: 50 mg/mL

Stringa SMILE

[Na+].CC1=CC(=O)Oc2cc([O-])ccc12

InChI

1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
JGMQHDNPUCPRQE-UHFFFAOYSA-M

Descrizione generale

4-methylumbelliferone (4-MU) is a coumarin derivative.

Applicazioni

4-Methylumbelliferone sodium salt has been used:
  • as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
  • as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
  • in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer

Azioni biochim/fisiol

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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PloS one, 6(11), e26773-e26773 (2011-11-19)
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337 and gus-wt genes were independently cloned
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