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K4518

Sigma-Aldrich

PKCγ, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinonimo/i:

MGC57564, PKC-gamma, PKCC, PKCG, PRK CG, SCA14

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About This Item

Numero MDL:
MFCD00241716
Codice UNSPSC:
12352200
NACRES:
NA.32

Ricombinante

expressed in baculovirus infected Sf9 cells

Livello qualitativo

200

Nome Commerciale

PRECISIO® Kinase

Saggio

≥70% (SDS-PAGE)

Forma fisica

buffered aqueous glycerol solution

Attività specifica

435-589 nmol/min·mg

PM

~105 kDa

N° accesso UniProt

P05129

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... PRKCG(5582)

Descrizione generale

PKCγ (protein kinase C γ) is a s a serine/threonine kinase belonging to the protein kinase C (PKC) family. PKCγ is mainly present in the central nervous system and is strongly expressed in cerebellar Purkinje cells.

Azioni biochim/fisiol

PKCγ (protein kinase C γ) is involved in cell proliferation, differentiation as well as migration. Mutations in PKCγ are associated with neurodegenerative disease, spinocerebellar ataxia type 14. Single nucleotide polymorphisms in PKCγ are also linked with high risk of osteosarcoma.

Stato fisico

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Note legali

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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Hideyuki Takahashi et al.
Human molecular genetics, 24(2), 525-539 (2014-09-14)
Amyloid assemblies are associated with a wide range of human disorders, including Alzheimer's and Parkinson's diseases. Here, we identify protein kinase C (PKC) γ, a serine/threonine kinase mutated in the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14), as a novel
Ying Zhang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12671-12677 (2014-09-26)
The objective of this study was to explore the relationship between single-nucleotide polymorphisms (SNPs) of the protein kinase C gamma (PRKCG) gene and osteosarcoma susceptibility in Chinese Han population. A total of 610 cases of osteosarcoma patients and 610 healthy
M Shamloo et al.
Neuroreport, 10(5), 931-935 (1999-05-13)
Neurons can be preconditioned against ischemic damage by a brief sublethal period of ischemia, applied several days before the second insult. Here we report on changes in the distribution and the levels of protein kinase Cgamma (PKCgamma) in nonconditioned and
J Rennecke et al.
European journal of biochemistry, 242(2), 428-432 (1996-12-01)
13 murine tissues and 12 cell lines were tested for the expression of the novel protein kinase C (PKC) isoenzyme mu. Using two different PKC mu antibodies (sc-639 and P26720), PKC mu was detected in all tissues and cells and
Huading Lu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(7), 5241-5247 (2015-02-11)
Osteosarcoma is a common malignant tumor, which exists widely in the bone of children and adolescents. Protein kinase C gamma (PRKCG) gene, which encodes γPKC, plays important roles in tumor promotion, cell proliferation, differentiation, and migration. The objective of the

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